Captain Isaac Ruddell (1737-January 1812) was an 18th-century American Virginia State Line officer during the American Revolutionary War and a Kentucky frontiersman. He was an officer commanding a company under BGEN George Rogers Clark (1777–1782). He was the founder of , or fort, on the Licking River in present-day Harrison County, Kentucky. In 1780, during the Revolutionary War, the settlement was destroyed by joint British Canadian and Eastern Woodlands Indian forces under British officer . He and his family were held prisoner in Detroit for over two years before their release.