Ise-Kamayama Domain (伊勢亀山藩, Ise-Kamayama-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Ise Province in what is part of now modern-day Kameyama, Mie. It was centered around Ise-Kameyama Castle. Ise-Kameyama Domain was controlled by fudai daimyō clans throughout most its history.