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About: JARID2     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Series108457976, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: ThingBiomoleculegeneBiomoleculeGeneyago:WikicatTranscriptionFactorsyago:Abstraction100002137yago:Arrangement107938773yago:Beginning107290905yago:Cause107326557yago:Event100029378yago:Factor107327805yago:Gene105436752yago:Group100031264yago:Happening107283608yago:Ordering108456993yago:Origin107323922yago:PsychologicalFeature100023100yago:WikicatGenesMutatedInMiceyago:YagoPermanentlyLocatedEntityHumanGeneproteinyago:Sequence108459252yago:Series108457976 New Facet based on Instances of this Class

Protein Jumonji is a protein that in humans is encoded by the JARID2 gene. JARID2 is a member of the alpha-ketoglutarate-dependent hydroxylase superfamily. Jarid2 (jumonji, AT rich interactive domain 2) is a protein coding gene that functions as a putative transcription factor. Distinguished as a nuclear protein necessary for mouse embryogenesis, Jarid2 is a member of the jumonji family that contains a DNA binding domain known as the AT-rich interaction domain (ARID). In vitro studies of Jarid2 reveal that ARID along with other functional domains are involved in DNA binding, nuclear localization, transcriptional repression, and recruitment of Polycomb-repressive complex 2 (PRC2). Intracellular mechanisms underlying these interactions remain largely unknown.