James Edward Shepard (November 3, 1875 – October 6, 1947) was an American pharmacist, civil servant and educator, the founder of what became the North Carolina Central University in Durham, North Carolina. He first established it as a private school for religious training in 1910 but adapted it as a school for teachers. He had a network of private supporters, including northern white philanthropists such as Olivia Slocum Sage of New York.