James Houston Spence, KC, (September 3, 1867 – February 21, 1939) was a Canadian lawyer and Senator. Spence was born in Greenock Township, Ontario and attended school in London, Ontario and Walkerton, Ontario. He graduated from Osgoode Hall Law School before being called to the bar. He was elected a Bencher of the Law Society of Upper Canada in 1917, named King's Counsel in 1922 and was the senior partner in the law firm of Spence, Shoemaker and Spence. He specialized in corporate, commercial and municipal law. He died at his home in Toronto on February 21, 1939.