Sir John Burgess Karslake, QC (13 December 1821 – 4 October 1881) was an English lawyer and politician. The son of Henry Karslake, a solicitor and Confidential Secretary to the Duke of Kent, by his wife Elizabeth Marsh Preston, the daughter of Richard Preston, Q.C. and sometime M.P. for Ashburton, he was educated at Harrow. His elder brother, Edward Kent Karslake (1820-1892), was a Q.C., sometime M.P. for Colchester and Fellow of Balliol College, Oxford. He was the brother or nephew of John Karslake Karslake.