John Francis Smithwick (1844 – 27 August 1913) was an Irish businessman and politician. John Francis Smithwick was a member of the Smithwick's brewing family and took over as head of the firm. He was active in local politics, twice becoming High Sheriff of County Kilkenny and once of Kilkenny City, of which he was mayor in 1884. He was the first chairman of Kilkenny County Council, and one of the Auditors of the National Bank.