John Salesbury (1533–1580), of Rûg, near Corwen, Merionethshire and Bachymbyd, near Ruthin, Denbighshire, was a Welsh politician. He was a Member (MP) of the Parliament of England for Denbigh Boroughs in April 1554 and 1558, for Denbighshire in 1559 and Merioneth in October 1553.