John de Vesci, sometimes spelt Vescy, was a prominent 13th-century noble. He was the eldest son of William de Vesci and Agnes de Ferrers. He married firstly Agnes de Saluzzo and secondly Isabella de Beaumont. John died c. 1289. John served in Wales in 1277. He married firstly Agnes de Saluzzo, daughter of Manfredo III, Marquis de Saluzzo and Beatrice de Savoy, before 1262. However, Agnes died very shortly afterwards. He married secondly Isabella de Beaumont sometime afterwards and was granted by Edward (now King Edward I of England) lands in Northumberland and Kent, including Eltham.