The Joseph Jenkins House is a historic house in Barnstable, Massachusetts. This 2+1⁄2-story wood-frame house was built c. 1750 by Joseph Jenkins, and is a well-preserved reminder of West Barnstable's early history. The house is four bays wide, with an off-center chimney and entry. The main entry has plain trim, with a transom window and a triangular pediment. The property was owned by the Jenkins family throughout the 19th century. The house was listed on the National Register of Historic Places in 1987.