Judith Smith Ladson (May 1766 – September 4, 1820) was an American heiress and socialite who served as the Second Lady of South Carolina. A member of the colonial planter class, she was the daughter of the slave trader Benjamin Smith and the wife of the politician James Ladson, who served as Lieutenant Governor of South Carolina. Through her marriage, she was a member of the Ladson family, one of Charleston's most prominent families.