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About: KLF12     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : dbo:Protein, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: ThingBiomoleculegeneBiomoleculeGeneyago:WikicatTranscriptionFactorsyago:Abstraction100002137yago:Beginning107290905yago:Cause107326557yago:Event100029378yago:Factor107327805yago:Happening107283608yago:Origin107323922yago:PsychologicalFeature100023100yago:YagoPermanentlyLocatedEntityHumanGeneprotein New Facet based on Instances of this Class

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene. Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.