Karen Jeppe (1 July 1876 – 7 July 1935) was a Danish missionary and social worker, known for her work with Ottoman Armenian refugees and survivors of the Armenian genocide, mainly widows and orphans, from 1903 untilher death in Syria in 1935. She was a member of Johannes Lepsius' Deutsche Orient-Mission (German Orient Mission) and assumed responsibility (in 1903) for the Armenian children in the Millet Khan German Refugee Orphanage after the 1895 Urfa massacres.