Kathryn "Kat" Elizabeth Holt is an Australian computational biologist specializing in infectious disease genomics. She is a professor at Monash University's Department of Infectious Diseases and a professor of Microbial Systems Genomics at the London School of Hygiene & Tropical Medicine (LSHTM). Her current research focuses on investigating the evolution and dissemination of antimicrobial resistance. In 2015, Holt received the L'Oréal-UNESCO International Rising Talent Award.