The Kennedy-Worthington Blocks are three historic commercial and industrial buildings at 1585-1623 Main Street and 166-190 Worthington Street in downtown Springfield, Massachusetts. Built in the 1870s and 1880s, with a major restyling to two of them in 1912, the buildings were a major factor in the urban development of the area north of the city's traditional core. They were listed to the National Register of Historic Places in 1979.