Komono Domain (菰野藩, Komono-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Ise Province in what is part of now modern-day town of Komono, Mie. It was centered around Komono jin'ya. Komono Domain was controlled by the tozama Hijikata clan throughout its history. Hijikata Toshizō, the famed leader of the pro-Tokugawa Shinsengumi during the Bakumatsu period was from a distance cadet branch of the Hijikata clan, and has no connection with this domain.