Lactose permease is a membrane protein which is a member of the major facilitator superfamily. Lactose permease can be classified as a symporter, which uses the proton gradient towards the cell to transport β-galactosides such as lactose in the same direction into the cell. The protein has twelve transmembrane alpha-helices and its molecular weight is 45,000 Daltons. It exhibits an internal two-fold symmetry, relating the N-terminal six helices onto the C-terminal helices. It is encoded by the lacY gene in the lac operon.
| Attributes | Values |
|---|
| rdf:type
| |
| rdfs:label
| - Lactosa permeasa (ca)
- Lactose perméase (fr)
- Lactose permease (en)
|
| rdfs:comment
| - La lactosa permeasa, també denominada permeasa de galactòsids, és una proteïna integral de membrana destinada al transport de lactosa, un disacàrid format per galactoses i glucoses present principalment a la llet i que és un nutrient essencial. El transport es dirigeix cap al medi intracel·lular en contra de gradient i quan la lactosa es torba a l'interior de la cèl·lula, s'escindeix en subunitats de monosacàrids. Aquest transportador ha estat molt estudiat durant les darreres dècades i es considera un arquetip útil per als transportadors secundaris que utilitzen un gradient de concentració per potenciar la formació d'un altre gradient. (ca)
- La lactose perméase est une protéine membranaire de la major facilitator superfamily. Il s'agit d'un symport β-galactoside/proton qui utilise le gradient de concentration en ions H+ pour absorber des β-galactosides tels que le lactose. Elle est codée par le gène de l'opéron lactose. (fr)
- Lactose permease is a membrane protein which is a member of the major facilitator superfamily. Lactose permease can be classified as a symporter, which uses the proton gradient towards the cell to transport β-galactosides such as lactose in the same direction into the cell. The protein has twelve transmembrane alpha-helices and its molecular weight is 45,000 Daltons. It exhibits an internal two-fold symmetry, relating the N-terminal six helices onto the C-terminal helices. It is encoded by the lacY gene in the lac operon. (en)
|
| name
| - LacY proton/sugar symporter (en)
|
| foaf:depiction
| |
| dct:subject
| |
| Wikipage page ID
| |
| Wikipage revision ID
| |
| Link from a Wikipage to another Wikipage
| |
| sameAs
| |
| TCDB
| |
| dbp:wikiPageUsesTemplate
| |
| thumbnail
| |
| PROSITE
| |
| caption
| - Crystal Structure of Lactose Permease in Complex with an Affinity Inactivator. PDB (en)
|
| InterPro
| |
| Pfam
| |
| Pfam clan
| |
| symbol
| |
| has abstract
| - La lactosa permeasa, també denominada permeasa de galactòsids, és una proteïna integral de membrana destinada al transport de lactosa, un disacàrid format per galactoses i glucoses present principalment a la llet i que és un nutrient essencial. El transport es dirigeix cap al medi intracel·lular en contra de gradient i quan la lactosa es torba a l'interior de la cèl·lula, s'escindeix en subunitats de monosacàrids. Aquest transportador ha estat molt estudiat durant les darreres dècades i es considera un arquetip útil per als transportadors secundaris que utilitzen un gradient de concentració per potenciar la formació d'un altre gradient. (ca)
- Lactose permease is a membrane protein which is a member of the major facilitator superfamily. Lactose permease can be classified as a symporter, which uses the proton gradient towards the cell to transport β-galactosides such as lactose in the same direction into the cell. The protein has twelve transmembrane alpha-helices and its molecular weight is 45,000 Daltons. It exhibits an internal two-fold symmetry, relating the N-terminal six helices onto the C-terminal helices. It is encoded by the lacY gene in the lac operon. The sugar lies in the hydrophilic core of the protein which is accessible from the periplasm. On binding, a large conformational change takes place which makes the sugar binding site accessible from the cytoplasm. Mechanism: hydronium ions from the outside of the cell binds to a carboxyl group on the enzyme that allows it to undergo a conformational change. This form of lactose permease can bind lactose from outside the cell. The enzyme then everts and lactose is transported inward. The X-ray crystal structure was first solved in 2003 by J. Abramson et al. (en)
- La lactose perméase est une protéine membranaire de la major facilitator superfamily. Il s'agit d'un symport β-galactoside/proton qui utilise le gradient de concentration en ions H+ pour absorber des β-galactosides tels que le lactose. Elle est codée par le gène de l'opéron lactose. (fr)
|
| OPM family
| |
| OPM protein
| |
| gold:hypernym
| |
| prov:wasDerivedFrom
| |
| page length (characters) of wiki page
| |
| Symbol
| |
| foaf:isPrimaryTopicOf
| |
| is Link from a Wikipage to another Wikipage
of | |
| is Wikipage redirect
of | |
| is foaf:primaryTopic
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)
