About: Large tumor antigen

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The large tumor antigen (also called the large T-antigen and abbreviated LTag or LT) is a protein encoded in the genomes of polyomaviruses, which are small double-stranded DNA viruses. LTag is expressed early in the infectious cycle and is essential for viral proliferation. Containing four well-conserved protein domains as well as several intrinsically disordered regions, LTag is a fairly large multifunctional protein; in most polyomaviruses, it ranges from around 600-800 amino acids in length. LTag has two primary functions, both related to replication of the viral genome: it unwinds the virus's DNA to prepare it for replication, and it interacts with proteins in the host cell to dysregulate the cell cycle so that the host's DNA replication machinery can be used to replicate the virus's g

Attributes	Values
rdfs:label	Großes T-Antigen (de) Large tumor antigen (en)
rdfs:comment	Das große T-Antigen (LTag oder LT, von engl. large ‚groß‘ und Tumor-Antigen) ist ein onkogenes und DNA-bindendes Protein des Simian-Virus 40 (SV40). Es wird in der Biochemie und Zellbiologie zur Immortalisierung von Säugetier-Zellen verwendet. Homologe kommen in anderen Polyomaviren vor, mit Längen zwischen 600 und 800 Aminosäuren. (de) The large tumor antigen (also called the large T-antigen and abbreviated LTag or LT) is a protein encoded in the genomes of polyomaviruses, which are small double-stranded DNA viruses. LTag is expressed early in the infectious cycle and is essential for viral proliferation. Containing four well-conserved protein domains as well as several intrinsically disordered regions, LTag is a fairly large multifunctional protein; in most polyomaviruses, it ranges from around 600-800 amino acids in length. LTag has two primary functions, both related to replication of the viral genome: it unwinds the virus's DNA to prepare it for replication, and it interacts with proteins in the host cell to dysregulate the cell cycle so that the host's DNA replication machinery can be used to replicate the virus's g (en)
foaf:depiction
dcterms:subject	Viral oncoproteins Polyomavirus proteins
Wikipage page ID	53151252 (xsd:integer)
Wikipage revision ID	1042954716 (xsd:integer)
Link from a Wikipage to another Wikipage	Protein-protein interaction Merkel cell Messenger RNA Merkel cell polyomavirus Topoisomerase 1 Human papillomavirus Replication protein A Cytoplasm DNA replication Early protein dbr:P53 Essential gene Viral oncoproteins Gene expression Genome Oligomer Origin of replication dbr:Retinoblastoma_protein Oncovirus Murine polyomavirus Macaca mulatta Major capsid protein VP1 Skin cancer Zinc Middle tumor antigen Polyomavirus proteins Translation (genetics) Tumor suppressor Helicase Nuclear localization sequence Adenosine triphosphate Amino acid Alternative splicing Cell culture Cell cycle Cell nucleus Globular protein Protein domain Protein International Committee on Taxonomy of Viruses ATP hydrolysis ATPase Chaperone protein Chimera (virus) Bioinformatics Double-stranded DNA virus Double helix C-terminus Phylogenetic Dodecamer Sequence motif Hexamer Merkel cell carcinoma S phase Exon Immortalised cell line SV40 large T antigen N-terminus Non-coding DNA SV40 Small tumor antigen Intrinsically disordered region Host cell Hsc70 heat-shock proteins Phosphorylated Oncoprotein DnaJ Polyomavirus Nbs1 AAA protein Conserved gene N-terminal Walker A box Capsid protein Sequence identity Neoplastic transformation
sameAs	Large tumor antigen Large tumor antigen Large tumor antigen Large tumor antigen
dbp:wikiPageUsesTemplate	dbt:Reflist dbt:Viral_proteins
thumbnail	wiki-commons:Special:FilePath/5tct_LTag_DNA.png?width=300
has abstract	Das große T-Antigen (LTag oder LT, von engl. large ‚groß‘ und Tumor-Antigen) ist ein onkogenes und DNA-bindendes Protein des Simian-Virus 40 (SV40). Es wird in der Biochemie und Zellbiologie zur Immortalisierung von Säugetier-Zellen verwendet. Homologe kommen in anderen Polyomaviren vor, mit Längen zwischen 600 und 800 Aminosäuren. (de) The large tumor antigen (also called the large T-antigen and abbreviated LTag or LT) is a protein encoded in the genomes of polyomaviruses, which are small double-stranded DNA viruses. LTag is expressed early in the infectious cycle and is essential for viral proliferation. Containing four well-conserved protein domains as well as several intrinsically disordered regions, LTag is a fairly large multifunctional protein; in most polyomaviruses, it ranges from around 600-800 amino acids in length. LTag has two primary functions, both related to replication of the viral genome: it unwinds the virus's DNA to prepare it for replication, and it interacts with proteins in the host cell to dysregulate the cell cycle so that the host's DNA replication machinery can be used to replicate the virus's genome. Some polyomavirus LTag proteins - most notably the well-studied SV40 large tumor antigen from the SV40 virus - are oncoproteins that can induce neoplastic transformation in the host cell. (en)
prov:wasDerivedFrom	wikipedia-en:Large_tumor_antigen?oldid=1042954716&ns=0

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