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Lethal white syndrome (LWS), also called overo lethal white syndrome (OLWS), lethal white overo (LWO), and overo lethal white foal syndrome (OLWFS), is an autosomal genetic disorder most prevalent in the American Paint Horse. Affected foals are born after the full 11-month gestation and externally appear normal, though they have all-white or nearly all-white coats and blue eyes. However, internally, these foals have a nonfunctioning colon. Within a few hours, signs of colic appear; affected foals die within a few days. Because the death is often painful, such foals are often humanely euthanized once identified. The disease is particularly devastating because foals are born seemingly healthy after being carried to full term.

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rdf:type
rdfs:label
  • Overo-Lethal-White-Gen (de)
  • Syndrome du poulain blanc (fr)
  • Lethal white syndrome (en)
  • Overo lethal white syndrome (sv)
rdfs:comment
  • Das Overo-Lethal-White-Gen ist ein Gen, welches bei der Vererbung der Fellfarbe bei Pferden beteiligt ist. Es vererbt sich unvollständig dominant und verursacht durch eine Mutation des Endothelin-Rezeptor-B-Locus Leuzismus. Ein Pferd, welches dieses Gen nur einmal erhält, zeigt gewöhnlich eine Frame-Overo-Scheckung und ist gesund. Wird das Lethal-White-Gen von beiden Elterntieren vererbt (liegt also homozygot vor), führt es zum OLWS (Overo-Lethal-White-Syndrom). (de)
  • Le syndrome du poulain blanc est une anomalie génétique létale chez le cheval, qui provoque la naissance de poulains portant une robe blanche à l'issue du croisement de deux chevaux de robe pie overo entre eux. (fr)
  • Lethal white syndrome (LWS), also called overo lethal white syndrome (OLWS), lethal white overo (LWO), and overo lethal white foal syndrome (OLWFS), is an autosomal genetic disorder most prevalent in the American Paint Horse. Affected foals are born after the full 11-month gestation and externally appear normal, though they have all-white or nearly all-white coats and blue eyes. However, internally, these foals have a nonfunctioning colon. Within a few hours, signs of colic appear; affected foals die within a few days. Because the death is often painful, such foals are often humanely euthanized once identified. The disease is particularly devastating because foals are born seemingly healthy after being carried to full term. (en)
  • Overo Lethal White Syndrom, eller OLWS, är en genetisk hästsjukdom som enbart drabbar skäckfärgade hästar, oftast Painthästar. Defekten gör även att fölet föds med ihopväxta tarmar och dör i akuta kolikattacker. Sjukdomen har alltid dödlig utgång hos fölen. Genen som orsakar defekten är densamma som ger skäckteckningen overo. (sv)
rdfs:seeAlso
foaf:name
  • Lethal white syndrome (en)
name
  • Lethal white syndrome (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/Creamwildponyfilly.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/Overo_paint_horse_by_Bonnie_Gruenberg.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/SabinoTestedNegforOLWS.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/Yukichan_20080427_001.jpg
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