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About: Levosimendan     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatAromaticCompoundsyago:WikicatCalciumSensitizersyago:WikicatNitrilesyago:Abstraction100002137yago:Activator114723079yago:AromaticCompound114610088yago:Chemical114806838yago:Compound114818238yago:Hydrocarbon114911057yago:Material114580897yago:Matter100020827yago:Nitrile114827346yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Relation100031921drugyago:Sensitizer114724025yago:Substance100019613umbel-rc:DrugProduct New Facet based on Instances of this Class

Levosimendan (INN) /ˌliːvoʊsaɪˈmɛndən/ is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It is marketed under the trade name Simdax (Orion Corporation). Overall the drug has a two fold mechanism of action. It leads to greater ionotrophy by increasing the calcium sensitivity as it binds to Troponin and this results in a greater positive iontrophic force. Secondly, the drug is able to open ATP sensitive potassium channels in vascular smooth muscle cells, and the vascular dilatory effects of the drug lead to a decreased pre-load and afterload, putting less work on the heart. This drug is in the process of review by the FDA but has not been approved yet.