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About: Limb development     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : dbo:Embryology, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingplacewikidata:Q4936952anatomical structureembryology New Facet based on Instances of this Class

Limb development in vertebrates is an area of active research in both developmental and evolutionary biology, with much of the latter work focused on the transition from fin to limb. Limb formation begins in the morphogenetic limb field, as mesenchymal cells from the lateral plate mesoderm proliferate to the point that they cause the ectoderm above to bulge out, forming a limb bud. Fibroblast growth factor (FGF) induces the formation of an organizer at the end of the limb bud, called the apical ectodermal ridge (AER), which guides further development and controls cell death. Programmed cell death is necessary to eliminate webbing between digits.