The Blood+ anime, light novel, and manga series features an extensive cast of characters designed by Chizu Hashii and co-created by Production I.G and Aniplex. The series is set within fictionalized versions of various real-life cities, including Okinawa, Japan; Hanoi, Vietnam; Yekaterinburg, Russia; Paris, France; London, England; Fayetteville, North Carolina; and New York City.