This is a list of mayors of the 50 largest cities in the United States, ordered by their estimated populations as of the 2020 Census. These 50 cities have a combined population of 49.6 million, or 15% of the national population. Louisville, Indianapolis, Jacksonville, Nashville, and Honolulu have consolidated city-county governments where the mayor is elected by residents of the entire county, not just that of the main city; in these cases the population and respective rank are for the county.