Lucy Weston Pickett (January 19, 1904 – November 23, 1997) was a Mary Lyon Professor and Camille and Henry Dreyfus Chair in Chemistry at Mount Holyoke College. Her research on X-ray crystallography and ultraviolet absorption spectroscopy of organic molecules received numerous honors and was supported by grants from the Office of Naval Research, the National Science Foundation and the Petroleum Research Fund of the American Chemical Society.