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The lung-on-a-chip is a complex, three-dimensional model of a living, breathing human lung on a microchip. The device is made using human lung and blood vessel cells and it can predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens. It can be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to animal testing.

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  • Lung-on-a-chip (en)
  • Lung-on-a-chip (ja)
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  • Lung-on-a-chipまたは肺機能チップとはチップ上に構成された肺の機能を持つ素子。 (ja)
  • The lung-on-a-chip is a complex, three-dimensional model of a living, breathing human lung on a microchip. The device is made using human lung and blood vessel cells and it can predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens. It can be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to animal testing. (en)
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  • The lung-on-a-chip is a complex, three-dimensional model of a living, breathing human lung on a microchip. The device is made using human lung and blood vessel cells and it can predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens. It can be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to animal testing. The lung-on-a-chip places two layers of living tissues—the lining of the lung's air sacs and the blood vessels that surround them—across a porous, flexible boundary. Air is delivered to the lung lining cells, a rich culture medium flows in the capillary channel to mimic blood, and cyclic mechanical stretching is generated by a vacuum applied to the chambers adjacent to the cell culture channels to mimic breathing. The research findings for lung-on-a-chip were published in the June 25, 2010, issue of Science, the academic journal of the American Association for the Advancement of Science. The research was funded by the National Institutes of Health, the American Heart Association, and the Wyss Institute for Biologically Inspired Engineering at Harvard University. (en)
  • Lung-on-a-chipまたは肺機能チップとはチップ上に構成された肺の機能を持つ素子。 (ja)
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