About: Lutetium (177Lu) oxodotreotide

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Lutetium (177Lu) oxodotreotide (INN) or 177Lu DOTA-TATE, trade name Lutathera, is a chelated complex of a radioisotope of the element lutetium with DOTA-TATE, used in peptide receptor radionuclide therapy (PRRT). Specifically, it is used in the treatment of cancers which express somatostatin receptors. Alternatives to 177Lu-DOTATE include yttrium-90 DOTATATE or DOTATOC. The longer range of the beta particles emitted by 90Y, which deliver the therapeutic effect, may make it more suitable for large tumors with 177Lu reserved for smaller volumes

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug drug
rdfs:label	177Lu-oxodotreotid (cs) Lutetium (177Lu) oxodotreotide (en) ルテチウムオキソドトレオチド (177Lu) (ja) Lutetium Lu 177 dotatate (ru)
rdfs:comment	ルテチウムオキソドトレオチド (177Lu)（Lutetium (177Lu) oxodotreotideまたは177Lu-ドータテート（177Lu DOTATATE）は、ルテチウムの放射性同位元素とオキソドトレオチドの錯体化合物であり、（PRRT）に使用される。具体的には、を発現する癌の治療に用いられる。 177Lu-ドータテートの代替品としては、イットリウム90-ドータテートや90Y-エドトレオチド（DOTATOC）がある。90Yは治療効果をもたらすβ粒子の飛距離が長いため、大きな腫瘍に適しており、177Luは小さな腫瘍に適していると考えられる。 (ja) Лютеций (177Lu) — радиофармацевтический препарат для лечения соматостатин-рецептор положительных гастроэнтеропанкреатических нейроэндокринных опухолей. Одобрен для применения: США (2018). (ru) Lutetium (177Lu) oxodotreotide (INN) or 177Lu DOTA-TATE, trade name Lutathera, is a chelated complex of a radioisotope of the element lutetium with DOTA-TATE, used in peptide receptor radionuclide therapy (PRRT). Specifically, it is used in the treatment of cancers which express somatostatin receptors. Alternatives to 177Lu-DOTATE include yttrium-90 DOTATATE or DOTATOC. The longer range of the beta particles emitted by 90Y, which deliver the therapeutic effect, may make it more suitable for large tumors with 177Lu reserved for smaller volumes (en)
foaf:name	Lutetium (177Lu) dotatate (en)
foaf:depiction
dcterms:subject	Chelating agents Macrocycles Radiopharmaceuticals Orphan drugs Lutetium complexes
Wikipage page ID	63892807 (xsd:integer)
Wikipage revision ID	1120348662 (xsd:integer)
Link from a Wikipage to another Wikipage	Cancer Priority review Arginine/lysine Beta particle Intravenous therapy Somatostatin receptor Chelating agents Macrocycles Chemical element Orphan drug Radiopharmaceutical Yttrium-90 Radiopharmaceuticals Advanced Accelerator Applications Amino acid Orphan drugs DOTA-TATE Erasmus MC European Commission Food and Drug Administration International Nonproprietary Name Kidney DOTATOC Neuroendocrine tumor Lutetium complexes Lutetium Intravenous Peptide receptor radionuclide therapy Radioisotope Chelator Beta radiation
Link from a Wikipage to an external page	https://druginfo.nlm.nih.gov/drugportal/name/lutetium%20lu%20177%20dotatate
sameAs	Lutetium (177Lu) oxodotreotide Lutetium (177Lu) oxodotreotide Lutetium (177Lu) oxodotreotide Lutetium (177Lu) oxodotreotide Lutetium (177Lu) oxodotreotide
dbp:wikiPageUsesTemplate	dbt:Cite_web dbt:Infobox_drug dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Cascite dbt:Fdacite dbt:Drugs.com dbt:Therapeutic_radiopharmaceuticals
thumbnail	wiki-commons:Special:FilePath/lutetium_(177Lu)_oxodotreotide.svg?width=300
ATC suffix	XX04 (en)
ATC prefix	V10 (en)
c	65 (xsd:integer)
CAS number	177943 (xsd:integer) 437608 (xsd:integer)
class	Antineoplastic agent (en)
drug name	Lutetium dotatate (en)
DrugBank	DB13985 (en)
H	87 (xsd:integer)
index2 label	acetate (en)
IUPAC name	lutetium 2-[4--7,10-bis-1,4,7,10-tetraazacyclododecan-1-yl]acetate (en)
KEGG	D11033 (en)
legal status	Rx-only (en)
legal UK	POM (en)
legal US	Rx-only (en)
n	14 (xsd:integer)
O	19 (xsd:integer)
PubChem	71587735 (xsd:integer)
routes of administration	Intravenous
s	2 (xsd:integer)
SMILES	CCO.[Lu+3] (en)
StdInChI	1 (xsd:integer)
StdInChIKey	MXDPZUIOZWKRAA-PRDSJKGBSA-K (en)
tradename	Lutathera (en)
UNII	99 (xsd:integer) AE221IM3BB (en)
width	300 (xsd:integer)
has abstract	Lutetium (177Lu) oxodotreotide (INN) or 177Lu DOTA-TATE, trade name Lutathera, is a chelated complex of a radioisotope of the element lutetium with DOTA-TATE, used in peptide receptor radionuclide therapy (PRRT). Specifically, it is used in the treatment of cancers which express somatostatin receptors. Alternatives to 177Lu-DOTATE include yttrium-90 DOTATATE or DOTATOC. The longer range of the beta particles emitted by 90Y, which deliver the therapeutic effect, may make it more suitable for large tumors with 177Lu reserved for smaller volumes The U.S. Food and Drug Administration (FDA) considers 177Lu dotatate to be a first-in-class medication. (en) ルテチウムオキソドトレオチド (177Lu)（Lutetium (177Lu) oxodotreotideまたは177Lu-ドータテート（177Lu DOTATATE）は、ルテチウムの放射性同位元素とオキソドトレオチドの錯体化合物であり、（PRRT）に使用される。具体的には、を発現する癌の治療に用いられる。 177Lu-ドータテートの代替品としては、イットリウム90-ドータテートや90Y-エドトレオチド（DOTATOC）がある。90Yは治療効果をもたらすβ粒子の飛距離が長いため、大きな腫瘍に適しており、177Luは小さな腫瘍に適していると考えられる。 (ja) Лютеций (177Lu) — радиофармацевтический препарат для лечения соматостатин-рецептор положительных гастроэнтеропанкреатических нейроэндокринных опухолей. Одобрен для применения: США (2018). (ru)
DailyMedID	Lutathera (en)
INN	lutetium oxodotreotide (en)

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