Mahyuddin Natimbul Same'a (14 September 1947 – 8 April 2021) was an Indonesian politician and academic who served as the vice governor of South Sumatra from 2003 to 2008 and as governor of South Sumatra in 2008. Following his five-month tenure as governor, Mahyuddin later served as a member of the People's Representative Council from 2009 to 2014.