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About: Mannomustine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Substance100019613, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatNitrogenMustardsyago:Abstraction100002137yago:Chemical114806838yago:Compound114818238yago:Material114580897yago:Matter100020827yago:NitrogenMustard114957649yago:Part113809207yago:PhysicalEntity100001930yago:Relation100031921drugyago:Substance100019613 New Facet based on Instances of this Class

Mannomustine (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from the group of nitrogen mustards. It was first synthesized and characterized in 1957 by Vargha et al. The mechanism of antineoplastic activity of mannomustine, like for all other alkylating agents, lies in its ability to alkylate DNA guanine nucleobases and, thus, to prevent uncoupling of DNA strands, which is a required step for any cell to divide.