Commandante Manuel Ascencio Padilla (or Manuel Ascensio Padilla) (September 26, 1774 – September 14, 1816) was an Upper Peruvian guerrilla chief who fought in the Bolivian War of Independence with his wife, Juana Azurduy de Padilla who shared his commitment towards Bolivian indigenous populations. The town of Padilla, Bolivia is named in his honor.