Manuela Santiago Collazo (1936–2010) was a Puerto Rican politician who was the mayor of the city of Vieques (1985–2001). Santiago Collazo became Vieques' first female mayor during the 1984 general elections. She remained in that position until 2001. Manuela Santiago Collazo did not seek re-election in the 2000 General Elections. She died on December 14, 2010.