Marie Desma Wilcox (November 24, 1933 – September 25, 2021) was a Native American who was the last native speaker of Wukchumni, a dialect of Tule-Kaweah, which is a Yokutsan indigenous language spoken by the Tule-Kaweah Yokuts of California. She worked for more than 20 years on a dictionary of the language and taught it.