Matsiloje is a village in the North East District of Botswana on the west bank of the Ramokgwebana River, which forms the border with Zimbabwe. A tarmac road connects the village to Francistown, to the east.The village has a junior secondary school.The village lies beside the Matsiloje hills, which are quarried for limestone used in manufacturing cement and soapstone products.The exploratory Muphanephane gold mine is in the Matsiloje area.