Melanocytic tumors of uncertain malignant potential (MELTUMP) are melanocytic lesions in the dermis that cannot be classified by morphology as either benign naevi (moles) or malignant melanomas because the mass shows features of both. Several lesion types may be classified as MELTUMPs: these include atypical melanocytic proliferations with features that may overlap with atypical Spitz naevi/tumors, dysplastic naevi, pigmented epithelioid melanocytoma, deep penetrating naevi, congenital naevi, cellular nodules in congenital naevi, possible naevoid melanomas, and cellular blue naevi.
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| - Tumori melanocitici di potenziale maligno incerto (it)
- Melanocytic tumors of uncertain malignant potential (en)
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| - Melanocytic tumors of uncertain malignant potential (MELTUMP) are melanocytic lesions in the dermis that cannot be classified by morphology as either benign naevi (moles) or malignant melanomas because the mass shows features of both. Several lesion types may be classified as MELTUMPs: these include atypical melanocytic proliferations with features that may overlap with atypical Spitz naevi/tumors, dysplastic naevi, pigmented epithelioid melanocytoma, deep penetrating naevi, congenital naevi, cellular nodules in congenital naevi, possible naevoid melanomas, and cellular blue naevi. (en)
- I tumori melanocitici con potenziale maligno incerto (MELTUMP) sono lesioni melanocitiche nel derma che non possono essere classificate dalla morfologia come nevi benigni o melanomi maligni perché la massa mostra caratteristiche comuni ad entrambi. (it)
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| - Melanocytic tumors of uncertain malignant potential (MELTUMP) are melanocytic lesions in the dermis that cannot be classified by morphology as either benign naevi (moles) or malignant melanomas because the mass shows features of both. Several lesion types may be classified as MELTUMPs: these include atypical melanocytic proliferations with features that may overlap with atypical Spitz naevi/tumors, dysplastic naevi, pigmented epithelioid melanocytoma, deep penetrating naevi, congenital naevi, cellular nodules in congenital naevi, possible naevoid melanomas, and cellular blue naevi. A related category of melanocytic proliferation is superficial atypical melanocytic proliferations of uncertain significance (SAMPUS). This category, unlike MELTUMP, which implies as yet undetermined potential for metastases even after complete excision, signifies lesions without metastatic potential at time of excision but with potential to progress upon incomplete excision. The SAMPUS category includes certain atypical junctional melanocytic proliferations and proliferations in both the epidermis and papillary dermis that are not accompanied by intradermal tumorigenic architecture or cell mitosis. (en)
- I tumori melanocitici con potenziale maligno incerto (MELTUMP) sono lesioni melanocitiche nel derma che non possono essere classificate dalla morfologia come nevi benigni o melanomi maligni perché la massa mostra caratteristiche comuni ad entrambi. Diversi tipi di lesione possono essere classificati come MELTUMP: questi includono proliferazioni melanocitiche atipiche con caratteristiche che possono sovrapporsi a nevi tumori atipici di Spitz, nevi displastici, melanocitoma epitelioide pigmentato, nevi con penetrazione profonda, nevi congeniti, noduli cellulari in nevi congeniti, nevi blu cellulari. Una categoria correlata di proliferazione melanocitica sono proliferazioni melanocitiche atipiche superficiali di significato incerto (SAMPUS). Questa categoria, a differenza di MELTUMP, che implica un potenziale ancora indeterminato di metastasi anche dopo l'escissione completa, indica lesioni senza potenziale metastatico al momento dell'escissione, ma con il potenziale di progredire su un'escissione incompleta. La categoria SAMPUS include alcune proliferazioni melanocitiche atipiche giunzionali e proliferazioni sia nell'epidermide che nel derma papillare che non sono accompagnate da architettura tumorale intradermica o mitosi cellulare. (it)
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