About: Melphalan flufenamide

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Melphalan flufenamide, sold under the brand name Pepaxto, is an anticancer medication used to treat multiple myeloma. The most common adverse reactions include fatigue, nausea, diarrhea, pyrexia and respiratory tract infection. Melphalan flufenamide is a peptidase enhanced cytotoxic (PEnC) that exerts a targeted delivery of melphalan in cells with high expression of aminopeptidases, such as aminopeptidase N, which has been described as over-expressed in human malignancies. Aminopeptidase N plays a functional role in malignant angiogenesis.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug drug
rdfs:label	Melphalan flufenamide (en)
rdfs:comment	Melphalan flufenamide, sold under the brand name Pepaxto, is an anticancer medication used to treat multiple myeloma. The most common adverse reactions include fatigue, nausea, diarrhea, pyrexia and respiratory tract infection. Melphalan flufenamide is a peptidase enhanced cytotoxic (PEnC) that exerts a targeted delivery of melphalan in cells with high expression of aminopeptidases, such as aminopeptidase N, which has been described as over-expressed in human malignancies. Aminopeptidase N plays a functional role in malignant angiogenesis. (en)
foaf:homepage	http://U.S.
foaf:depiction
dct:subject	Alkylating agents Prodrugs Orphan drugs Cancer treatments Dipeptides
Wikipage page ID	49620393 (xsd:integer)
Wikipage revision ID	1121586776 (xsd:integer)
Link from a Wikipage to another Wikipage	Alkylating agents Prodrugs Melphalan Multiple myeloma Committee for Medicinal Products for Human Use Orphan drugs Dana–Farber Cancer Institute European Medicines Agency Food and Drug Administration Angiogenesis Cancer treatments Dipeptides Chemotherapy dbr:Alanine_aminopeptidase Aminopeptidase N Aminopeptidases Anticancer medication dbr:%3C/nowiki%3E(2''S'')-2-amino-3-%5B4-%5Bbis(2-chloroethyl)amino%5Dphenyl%5Dpropanoyl%5Damino%5D-3-(4-fluorophenyl)propanoate
Link from a Wikipage to an external page	https://www.fda.gov/drugs/drug-safety-and-availability/fda-alerts-patients-and-health-care-professionals-about-clinical-trial-results-showing-increased https://druginfo.nlm.nih.gov/drugportal/name/melphalan%20flufenamide
sameAs	Melphalan flufenamide Melphalan flufenamide
dbp:wikiPageUsesTemplate	dbt:Chemotherapeutic_agents dbt:Cite_web dbt:Infobox_drug dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Drugs.com dbt:Medcn dbt:ClinicalTrialsGov
thumbnail	wiki-commons:Special:FilePath/Melphalan_flufenamide.svg?width=300
ATC suffix	AA10 (en)
ATC prefix	L01 (en)
c	24 (xsd:integer)
CAS number	380449 (xsd:integer)
ChEMBL	4303060 (xsd:integer)
ChemSpiderID	8111267 (xsd:integer)
Cl	2 (xsd:integer)
DrugBank	DB16627 (en)
elimination half-life	600.0 (second)
F	1 (xsd:integer)
H	30 (xsd:integer)
IUPAC name	Ethyl -2-(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate (en)
legal US	Rx-only (en)
metabolism	Aminopeptidase hydrolysis, Spontaneous hydrolyisis on N-mustard (en)
n	3 (xsd:integer)
O	3 (xsd:integer)
PubChem	9935639 (xsd:integer)
SMILES	CCOC[C@H]NC[C@H]N (en)
StdInChI	1 (xsd:integer)
StdInChIKey	YQZNKYXGZSVEHI-VXKWHMMOSA-N (en)
synonyms	Melflufen, 4-[Bis-amino]-(L)-phenylalanine-4-fluoro-(L)-phenylalanine ethyl ester, J1 (en)
tradename	Pepaxto (en)
UNII	F70C5K4786 (en)
has abstract	Melphalan flufenamide, sold under the brand name Pepaxto, is an anticancer medication used to treat multiple myeloma. The most common adverse reactions include fatigue, nausea, diarrhea, pyrexia and respiratory tract infection. Melphalan flufenamide is a peptidase enhanced cytotoxic (PEnC) that exerts a targeted delivery of melphalan in cells with high expression of aminopeptidases, such as aminopeptidase N, which has been described as over-expressed in human malignancies. Aminopeptidase N plays a functional role in malignant angiogenesis. Melphalan flufenamide was approved for medical use in the United States in February 2021. (en)
DailyMedID	Melphalan_flufenamide (en)
prov:wasDerivedFrom	wikipedia-en:Melphalan_flufenamide?oldid=1121586776&ns=0
page length (characters) of wiki page	25611 (xsd:nonNegativeInteger)
alternative name	Pepaxto (en)
CAS number	380449-51-4
ChEMBL	4303060
DrugBank	DB16627
FDA UNII code	F70C5K4786
PubChem	9935639
foaf:isPrimaryTopicOf	wikipedia-en:Melphalan_flufenamide
is Link from a Wikipage to another Wikipage of	Pepaxto Melflufen ATC code L01 Melphalan flufenamide hydrochloride
is Wikipage redirect of	Pepaxto Melflufen Melphalan flufenamide hydrochloride
is foaf:primaryTopic of	wikipedia-en:Melphalan_flufenamide

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