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Metastatic calcification is deposition of calcium salts in otherwise normal tissue, because of elevated serum levels of calcium, which can occur because of deranged metabolism as well as increased absorption or decreased excretion of calcium and related minerals, as seen in hyperparathyroidism. Metastatic calcification can occur widely throughout the body but principally affects the interstitial tissues of the vasculature, kidneys, lungs, and gastric mucosa. For the latter three, acid secretions or rapid changes in pH levels contribute to the formation of salts.

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  • Kalsifikasi metastatik (in)
  • Calcificazione metastatica (it)
  • Metastatic calcification (en)
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  • Kalsifikasi metastatik adalah deposisi di jaringan normal, umumnya akibat hiperkalsemia atau tingginya kadar kalsium di dalam serum. Penyebab utama hiperkalsemia yaitu peningkatan sekresi hormon (hiperparatiroidisme), destruksi tulang, kelainan yang berhubungan dengan Vitamin D, dan gagal ginjal. Kalsifikasi metastatik dapat terjadi secara luas di dalam tubuh, tetapu umumnya memengaruhi dari pembuluh darah, ginjal, paru-paru, dan . Dalam tiga contoh yang disebut terakhir, sekresi asam atau perubahan drastis tingkat pH menjadi faktor terbentuknya garam. (in)
  • Metastatic calcification is deposition of calcium salts in otherwise normal tissue, because of elevated serum levels of calcium, which can occur because of deranged metabolism as well as increased absorption or decreased excretion of calcium and related minerals, as seen in hyperparathyroidism. Metastatic calcification can occur widely throughout the body but principally affects the interstitial tissues of the vasculature, kidneys, lungs, and gastric mucosa. For the latter three, acid secretions or rapid changes in pH levels contribute to the formation of salts. (en)
  • La calcificazione metastatica in campo medico, è un processo patologico di deposizione eterotopica di calcio in tessuti sani dovuto ad un'anomalia dei processi metabolici del calcio. Le calcificazioni metastatiche si differenziano dalle calcificazioni distrofiche in quanto queste ultime avvengono in tessuti necrotici o in via di degenerazione. Questo tipo di calcificazione si presenta come deposizione di sali di calcio (principalmente cristalli di idrossiapatite) in un range ristretto di tessuti caratterizzati da un ambiente interno altamente alcalino, in quanto sedi di neutralizzazione di acidi; tra questi vi sono le vene polmonari e le arterie sistemiche nelle quali scorre un sangue a basso contenuto di bicarbonato, i polmoni e la cornea poiché entrambi eliminano CO2 (i primi tramite la (it)
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  • Metastatic calcification is deposition of calcium salts in otherwise normal tissue, because of elevated serum levels of calcium, which can occur because of deranged metabolism as well as increased absorption or decreased excretion of calcium and related minerals, as seen in hyperparathyroidism. In contrast, dystrophic calcification is caused by abnormalities or degeneration of tissues resulting in mineral deposition, though blood levels of calcium remain normal. These differences in pathology also mean that metastatic calcification is often found in many tissues throughout a person or animal, whereas dystrophic calcification is localized. Metastatic calcification can occur widely throughout the body but principally affects the interstitial tissues of the vasculature, kidneys, lungs, and gastric mucosa. For the latter three, acid secretions or rapid changes in pH levels contribute to the formation of salts. (en)
  • Kalsifikasi metastatik adalah deposisi di jaringan normal, umumnya akibat hiperkalsemia atau tingginya kadar kalsium di dalam serum. Penyebab utama hiperkalsemia yaitu peningkatan sekresi hormon (hiperparatiroidisme), destruksi tulang, kelainan yang berhubungan dengan Vitamin D, dan gagal ginjal. Kalsifikasi metastatik dapat terjadi secara luas di dalam tubuh, tetapu umumnya memengaruhi dari pembuluh darah, ginjal, paru-paru, dan . Dalam tiga contoh yang disebut terakhir, sekresi asam atau perubahan drastis tingkat pH menjadi faktor terbentuknya garam. (in)
  • La calcificazione metastatica in campo medico, è un processo patologico di deposizione eterotopica di calcio in tessuti sani dovuto ad un'anomalia dei processi metabolici del calcio. Le calcificazioni metastatiche si differenziano dalle calcificazioni distrofiche in quanto queste ultime avvengono in tessuti necrotici o in via di degenerazione. Questo tipo di calcificazione si presenta come deposizione di sali di calcio (principalmente cristalli di idrossiapatite) in un range ristretto di tessuti caratterizzati da un ambiente interno altamente alcalino, in quanto sedi di neutralizzazione di acidi; tra questi vi sono le vene polmonari e le arterie sistemiche nelle quali scorre un sangue a basso contenuto di bicarbonato, i polmoni e la cornea poiché entrambi eliminano CO2 (i primi tramite la respirazione mentre invece la cornea tramite i processi ciliari), la mucosa gastrica che secerne HCl ed infine i reni che sono responsabili dell'escrezione di idrogenioni. (it)
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