Methylmethaqualone (MMQ) is a quinazolinone and an analogue of methaqualone that has similar sedative and hypnotic properties to its parent compound (resulting from its agonist activity at the β subtype of the GABAA receptor), and is much more potent. Methylmethaqualone differs from methaqualone by 4-methylation on the phenyl ring. It was made illegal in Germany in 1999 and listed by the DEA as a "drug of forensic interest" at about the same time, but little other information is available. It would appear that this compound was sold on the black market in Germany as a designer drug analogue of methaqualone.
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| - メチルメタカロン (ja)
- Methylmethaqualone (en)
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| - メチルメタカロン(Methylmethaqualone)は、キナゾリノン系ののアナログで、β型のGABAA受容体アゴニスト活性に由来する、メタカロンと似た、ほぼ同じ強さの催眠/鎮静作用を有する。メチルメタカロンは、メタカロンのフェニル環の4位がメチル化している。ドイツでは1999年に非合法化し、アメリカの麻薬取締局ではほぼ同時期に"drug of forensic interest"として記載された。この化合物は、ドイツの闇市場で、メタカロンのアナログのデザイナードラッグとして販売されていると見られている。 動物実験により、鎮静の効果のある投与量を少し超えると、痙攣を誘発することが示され、またヒトの利用で痙攣が促進されうるという報告もあった。 (ja)
- Methylmethaqualone (MMQ) is a quinazolinone and an analogue of methaqualone that has similar sedative and hypnotic properties to its parent compound (resulting from its agonist activity at the β subtype of the GABAA receptor), and is much more potent. Methylmethaqualone differs from methaqualone by 4-methylation on the phenyl ring. It was made illegal in Germany in 1999 and listed by the DEA as a "drug of forensic interest" at about the same time, but little other information is available. It would appear that this compound was sold on the black market in Germany as a designer drug analogue of methaqualone. (en)
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| - Methylmethaqualone (MMQ) is a quinazolinone and an analogue of methaqualone that has similar sedative and hypnotic properties to its parent compound (resulting from its agonist activity at the β subtype of the GABAA receptor), and is much more potent. Methylmethaqualone differs from methaqualone by 4-methylation on the phenyl ring. It was made illegal in Germany in 1999 and listed by the DEA as a "drug of forensic interest" at about the same time, but little other information is available. It would appear that this compound was sold on the black market in Germany as a designer drug analogue of methaqualone. Animal studies of methylmethaqualone have shown it to produce convulsions at only slightly above the effective sedative dose, and anecdotal reports from human users have confirmed that it can have a pro-convulsive effect, which has potential to make this compound particularly hazardous if taken in excessive doses. (en)
- メチルメタカロン(Methylmethaqualone)は、キナゾリノン系ののアナログで、β型のGABAA受容体アゴニスト活性に由来する、メタカロンと似た、ほぼ同じ強さの催眠/鎮静作用を有する。メチルメタカロンは、メタカロンのフェニル環の4位がメチル化している。ドイツでは1999年に非合法化し、アメリカの麻薬取締局ではほぼ同時期に"drug of forensic interest"として記載された。この化合物は、ドイツの闇市場で、メタカロンのアナログのデザイナードラッグとして販売されていると見られている。 動物実験により、鎮静の効果のある投与量を少し超えると、痙攣を誘発することが示され、またヒトの利用で痙攣が促進されうるという報告もあった。 (ja)
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