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Methyprylon, or Noludar, is a sedative of the piperidinedione derivative family first developed by Hoffmann-La Roche.This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with fewer side effects, such as benzodiazepines. Methyprylon was withdrawn from the US market in June 1975 and the Canadian market in September 1990.Some other trade names are Noctan and Dimerin.

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  • Methyprylon (de)
  • Metiprilon (es)
  • Metiprilone (it)
  • Methyprylon (en)
  • Metyprylon (pl)
  • Metyprylon (sv)
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  • Methyprylon ist ein Arzneistoff, der als Sedativum und Hypnotikum verwendet wurde. Es wurde 1954 für Hoffmann-La Roche patentiert und war in Deutschland unter dem Handelsnamen Noludar® ab 1955 auf dem Markt. Chemisch gesehen gehört es – wie auch Glutethimid, Pyrithyldion und Thalidomid – zur Gruppe der Piperidindione. Diese wiederum sind strukturelle Abwandlungen der Barbiturate. (de)
  • El metiprilon es un fármaco hipnótico y sedante derivado de la piperidinediona, igual que la Glutetimida.​ (es)
  • Methyprylon, or Noludar, is a sedative of the piperidinedione derivative family first developed by Hoffmann-La Roche.This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with fewer side effects, such as benzodiazepines. Methyprylon was withdrawn from the US market in June 1975 and the Canadian market in September 1990.Some other trade names are Noctan and Dimerin. (en)
  • Metyprylon – organiczny związek chemiczny stosowany jako lek nasenny i uspokajający, jest objęty Konwencją o substancjach psychotropowych z 1971 roku (wykaz IV). W Polsce jest w grupie IV-P Ustawy o przeciwdziałaniu narkomanii. (pl)
  • Il metiprilone, derivato piperidinico strutturalmente correlato alla glutetimide, svolge un'attività deprimente del sistema nervoso centrale simile a quella dei barbiturici. Il suo meccanismo d'azione è ancora sconosciuto, ma studi effettuati su animali di laboratorio hanno permesso di stabilire che il farmaco innalza la soglia dei centri della veglia nel cervello. A seconda della dose somministrata il metiprilone agisce come sedativo o come ipnotico. Così come i barbiturici, anche il metiprilone sopprime la fase REM del sonno. Esso induce il sonno entro 45 minuti dalla somministrazione e il suo effetto ipnotico si protrae per 5-8 ore. Il mattino successivo alla somministrazione di una dose, nonostante la sua breve emivita, il metiprilone può produrre un effetto hangover. Da studi effettua (it)
  • Metyprylon, C10H17NO2, är ett lugnande, sömngivande och narkotikaklassat preparat. Läkemedlet har använts för behandling av sömnlöshet, men används numera sällan eftersom det har ersatts med modernare läkemedel med färre biverkningar, såsom bensodiazepiner. Metyprylon patenterades 1954 av Hoffman-La Roche och förekom på marknaden under handelsnamnet Noludar®. Metyprylon drogs tillbaka från den amerikanska marknaden i juni 1965, den svenska marknaden i juli 1988 och den kanadensiska marknaden i september 1990. (sv)
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  • CE02 (en)
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  • N05 (en)
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