Milk River Natural Area is a provincially designated protected area in the southeastern corner of the province of Alberta, Canada, approximately 160 km south of the city of Medicine Hat. It lies primarily in the County of Forty Mile with a small portion in southwest Cypress County. On the Alberta Township System (ATS) grid it is located in portions of Township 1, Range 5 and 6, and Township 2, Range 6, west of the Fourth Meridian.