About: Mir-223

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In molecular biology MicroRNA-223 (miR-223) is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-223 is a hematopoietic specific microRNA with crucial functions in myeloid lineage development. It plays an essential role in promoting granulocytic differentiation while also being associated with the suppression of erythrocytic differentiation. miR-223 is commonly repressed in hepatocellular carcinoma and leukemia. Higher expression levels of miRNA-223 are associated with extranodal marginal-zone lymphoma of mucosa-associated lymphoid tissue of the stomach and recurrent ovarian cancer. In some cancers the microRNA-223 down-regulation is correlated with higher tumor burden, disease aggressiveness, and poor prognostic factors. M

Attributes	Values
rdf:type	chemical compound
rdfs:label	Mir-223 (en)
rdfs:comment	In molecular biology MicroRNA-223 (miR-223) is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-223 is a hematopoietic specific microRNA with crucial functions in myeloid lineage development. It plays an essential role in promoting granulocytic differentiation while also being associated with the suppression of erythrocytic differentiation. miR-223 is commonly repressed in hepatocellular carcinoma and leukemia. Higher expression levels of miRNA-223 are associated with extranodal marginal-zone lymphoma of mucosa-associated lymphoid tissue of the stomach and recurrent ovarian cancer. In some cancers the microRNA-223 down-regulation is correlated with higher tumor burden, disease aggressiveness, and poor prognostic factors. M (en)
name	mir-223 (en) mir-223 microRNA precursor family (en)
foaf:depiction
dcterms:subject	MicroRNA
Wikipage page ID	29446415 (xsd:integer)
Wikipage revision ID	1123748827 (xsd:integer)
Link from a Wikipage to another Wikipage	Ephrin A1 FBXW7 MicroRNA STMN1 MicroRNA Rheumatoid arthritis Cyclin E E2F1 Chronic lymphocytic leukemia NFIA Osteoclast Leukemia MALT lymphoma Diabetes mellitus type 1 Type 2 diabetes Acute lymphoblastic leukemia Acute myeloid leukemia Eukaryote Euteleostomi Granulocyte Granulopoiesis RHOB Hematopoietic Hepatocellular carcinoma Ischemia ACSL1 AU-rich element Biomarker Diabetes Glut4 Sepsis Mast cell Systemic inflammatory response syndrome Ccaat-enhancer-binding proteins Non-coding RNA LMO2 RhoB Ovarian cancer Myeloid PU.1 Glucose metabolism Erythrocytic Erythroid Hematopoiesis Monocytic dbr:MicroRNA-146a
sameAs	Mir-223 Mir-223 Mir-223
Tax domain	Eukaryota; Euteleostomi (en)
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Reflist dbt:Short_description dbt:Use_dmy_dates dbt:Infobox_rfam dbt:Rfam dbt:MiRNA_precursor_families
thumbnail	wiki-commons:Special:FilePath/MiR-223_secondary_structure.png?width=300
OMIM	300694 (xsd:integer)
caption	miR-223 microRNA secondary structure and sequence conservation (en)
id	RF00664 (en)
symbol	mir-223 (en)
width	220 (xsd:integer)
has abstract	In molecular biology MicroRNA-223 (miR-223) is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-223 is a hematopoietic specific microRNA with crucial functions in myeloid lineage development. It plays an essential role in promoting granulocytic differentiation while also being associated with the suppression of erythrocytic differentiation. miR-223 is commonly repressed in hepatocellular carcinoma and leukemia. Higher expression levels of miRNA-223 are associated with extranodal marginal-zone lymphoma of mucosa-associated lymphoid tissue of the stomach and recurrent ovarian cancer. In some cancers the microRNA-223 down-regulation is correlated with higher tumor burden, disease aggressiveness, and poor prognostic factors. MicroRNA-223 is also associated with rheumatoid arthritis, sepsis, type 2 diabetes, and hepatic ischemia. (en)
EntrezGene	407008 (xsd:integer)
HGNCid	31603 (xsd:integer)
miRBase family	MIPF0000067 (en)
Rfam	RF00664 (en)
RNA type	MicroRNA
gold:hypernym	Molecule
prov:wasDerivedFrom	wikipedia-en:Mir-223?oldid=1123748827&ns=0
page length (characters) of wiki page	16348 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Mir-223
is Link from a Wikipage to another Wikipage of	Mir-126 Mir-223 microRNA Mir223
is Wikipage redirect of	Mir-223 microRNA Mir223
is foaf:primaryTopic of	wikipedia-en:Mir-223

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