The Mississippi County Jail was a historic county jail building in Osceola, Arkansas. It was a three-story brick structure, six bays wide, with entrances at the outer two bays, which projected slightly and were set off from the central portion by brick pilasters and a decorative parapet at the roof line. The county built the jail in 1926; it was demolished in 2016. The building was listed on the National Register of Historic Places in 1987. It was delisted in 2017.