Mississippi Highway 407 (MS 407) is a two-lane wide state highway in central Mississippi consisting of two separate segments. The first segment connects the towns of McCool and Weir with MS 12 and is signed a north-south route. The second segment runs from French Camp at MS 413 west (but again signed north-south) to Winona at U.S. Route 51 (US 51). Most of the road is state maintained, however, a 5.5-mile-long (8.9 km) segment between McCool and Weir are maintained as county roads.