Route 75 is a short highway in Mississippi County in the U.S. state of Missouri. Its southern terminus is at Route 80, and it travels north through farmland to the town of Anniston. It then travels westward to its northern terminus at Route 105 north of East Prairie. The route was designated in 1968, after Route 77 was moved to a new alignment east of Anniston, and the remaining section was renumbered to Route 75.