About: Molecular Inversion Probe

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Molecular Inversion Probe (MIP) belongs to the class of Capture by Circularization molecular techniques for performing genomic partitioning, a process through which one captures and enriches specific regions of the genome. Probes used in this technique are single stranded DNA molecules and, similar to other genomic partitioning techniques, contain sequences that are complementary to the target in the genome; these probes hybridize to and capture the genomic target. MIP stands unique from other genomic partitioning strategies in that MIP probes share the common design of two genomic target complementary segments separated by a linker region. With this design, when the probe hybridizes to the target, it undergoes an inversion in configuration (as suggested by the name of the technique) and c

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rdfs:label	Molecular Inversion Probe (en)
rdfs:comment	Molecular Inversion Probe (MIP) belongs to the class of Capture by Circularization molecular techniques for performing genomic partitioning, a process through which one captures and enriches specific regions of the genome. Probes used in this technique are single stranded DNA molecules and, similar to other genomic partitioning techniques, contain sequences that are complementary to the target in the genome; these probes hybridize to and capture the genomic target. MIP stands unique from other genomic partitioning strategies in that MIP probes share the common design of two genomic target complementary segments separated by a linker region. With this design, when the probe hybridizes to the target, it undergoes an inversion in configuration (as suggested by the name of the technique) and c (en)
foaf:depiction
dcterms:subject	Genomics techniques
Wikipage page ID	26061258 (xsd:integer)
Wikipage revision ID	1123483124 (xsd:integer)
Link from a Wikipage to another Wikipage	Primer (molecular biology) Endometrium Multiplex (assay) Mutation Nucleotide Allele Restriction enzymes Cystic fibrosis DNA DNA microarray DNA polymerase International HapMap Project Polymerase chain reaction Ligase Nucleic acid hybridization Complementarity (molecular biology) Genome Genome-wide association study Genotyping Oligonucleotide Zygosity Quantitative trait locus Glioma Copy number variation Leukemia Deletion (genetics) Karyotype Linkage disequilibrium Locus (genetics) Pharmacogenomics 454 Life Sciences Genomics techniques DNA sequencing Exome Base pair Fluorescence in situ hybridization Precision and recall Receptor (biochemistry) Restriction enzyme Rolling circle replication Covalent bond ABI Solid Sequencing Accuracy and precision Biomarker Biotinylation Illumina (company) Metastasis Caspase Single-nucleotide polymorphism Sensitivity and specificity Exon Exon trapping Exonuclease In situ hybridization Restriction site Fixation (histology) Molecular biology SNP array SNP genotyping HapMap Array comparative genomic hybridization GC content Heterozygotic
Link from a Wikipage to an external page	http://bioel.stanford.edu:16080/CIPer/ https://web.archive.org/web/20110720045248/http:/bioel.stanford.edu/CIPer/ https://www.ncbi.nlm.nih.gov/projects/genome/probe/doc/TechMIP.shtml
sameAs	Molecular Inversion Probe Molecular Inversion Probe Molecular Inversion Probe
dbp:wikiPageUsesTemplate	dbt:Dead_link dbt:Reflist
thumbnail	wiki-commons:Special:FilePath/MIP_probe_details_timothy_final.png?width=300
bot	InternetArchiveBot (en)
date	February 2018 (en)
fix-attempted	yes (en)
has abstract	Molecular Inversion Probe (MIP) belongs to the class of Capture by Circularization molecular techniques for performing genomic partitioning, a process through which one captures and enriches specific regions of the genome. Probes used in this technique are single stranded DNA molecules and, similar to other genomic partitioning techniques, contain sequences that are complementary to the target in the genome; these probes hybridize to and capture the genomic target. MIP stands unique from other genomic partitioning strategies in that MIP probes share the common design of two genomic target complementary segments separated by a linker region. With this design, when the probe hybridizes to the target, it undergoes an inversion in configuration (as suggested by the name of the technique) and circularizes. Specifically, the two target complementary regions at the 5’ and 3’ ends of the probe become adjacent to one another while the internal linker region forms a free hanging loop. The technology has been used extensively in the HapMap project for large-scale SNP genotyping as well as for studying gene copy alterationsand characteristics of specific genomic loci to identify biomarkers for different diseases such as cancer. Key strengths of the MIP technology include its high specificity to the target and its scalability for high-throughput, multiplexed analyses where tens of thousands of genomic loci are assayed simultaneously. (en)
prov:wasDerivedFrom	wikipedia-en:Molecular_Inversion_Probe?oldid=1123483124&ns=0
page length (characters) of wiki page	40715 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Molecular_Inversion_Probe
is Link from a Wikipage to another Wikipage of	MIP
is Wikipage disambiguates of	MIP
is foaf:primaryTopic of	wikipedia-en:Molecular_Inversion_Probe

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