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About: Morphiceptin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatPeptides, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatOpioidPeptidesyago:Abstraction100002137yago:Amide114724264yago:Chemical114806838yago:Compound114818238yago:Material114580897yago:Matter100020827yago:OrganicCompound114727670yago:Part113809207yago:Peptide114743046yago:PhysicalEntity100001930yago:Relation100031921chemical compoundyago:Substance100019613yago:WikicatPeptides New Facet based on Instances of this Class

Morphiceptin is a tetrapeptide (Tyr-Pro-Phe-Pro-NH2) that is a selective μ-opioid receptor agonist. It is derived from β-casomorphin and has over 1,000 times selectivity for μ- over δ-opioid receptors. When injected intracerebroventricularly (into the ventricular system of the brain), morphiceptin had an analgesic ED50 of 1.7 nmol per animal. The analgesic effects of morphiceptin were reversed by naloxone, meaning that the analgesic effect is mediated by the μ-opioid receptor. Morphiceptin is the (1S,2S,3S,4S)-form whereas is the (1S,2S,3S,4R)-form [84799-23-5].