Mouse Creek is a tributary of Schwaben Creek in Northumberland County, Pennsylvania, in the United States. It is approximately 5.6 miles (9.0 km) long and flows through Jordan Township, Washington Township, and Jackson Township. The watershed of the creek has an area of 7.19 square miles (18.6 km2). The creek and its tributaries are not designated as impaired waterbodies. Its watershed is at least partially in the ridge and valley physiographic province. The main land use in the upper reaches of the creek's drainage basin are forested land and agricultural land, but other land uses exist as well. A number of bridges have been constructed across the creek.