The Myrtle Street School is a historic school at 64 Myrtle Street in the Indian Orchard neighborhood of Springfield, Massachusetts. Built in stages between 1868 and 1915, it encapsulates changing trends in school design over that period of time, and is a good example of a school building with Second Empire and Classical Revival features. It was listed on the National Register of Historic Places in 1985. It has been converted to residential use.