About: Mytatrienediol

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Mytatrienediol (developmental code name SC-6924; former tentative brand names Manvene, Anvene), also known as 16α-methyl-16β-epiestriol 3-methyl ether or 16β-hydroxy-16α-methylestradiol 3-methyl ether, is a synthetic steroidal estrogen medication and an estrogen ether which was derived from estriol and was developed for clinical use in the late 1950s but was never marketed. It was investigated as a weak and mildly estrogenic medication for men to treat atherosclerosis, improve serum lipid profiles, and reduce the risk of myocardial infarction. However, while preclinical research supported the profile of mytatriendiol as a weak estrogen, the medication was found in clinical trials to produce estrogenic side effects including feminization, breast pain, and gynecomastia in men similarly and c

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug drug
rdfs:label	Mytatrienediol (en)
rdfs:comment	Mytatrienediol (developmental code name SC-6924; former tentative brand names Manvene, Anvene), also known as 16α-methyl-16β-epiestriol 3-methyl ether or 16β-hydroxy-16α-methylestradiol 3-methyl ether, is a synthetic steroidal estrogen medication and an estrogen ether which was derived from estriol and was developed for clinical use in the late 1950s but was never marketed. It was investigated as a weak and mildly estrogenic medication for men to treat atherosclerosis, improve serum lipid profiles, and reduce the risk of myocardial infarction. However, while preclinical research supported the profile of mytatriendiol as a weak estrogen, the medication was found in clinical trials to produce estrogenic side effects including feminization, breast pain, and gynecomastia in men similarly and c (en)
foaf:depiction
dct:subject	Abandoned drugs Diols Estranes Estrogen ethers Synthetic estrogens Hypolipidemic agents
Wikipage page ID	51508304 (xsd:integer)
Wikipage revision ID	1084549142 (xsd:integer)
Link from a Wikipage to another Wikipage	List of estrogen esters Abandoned drugs Diols Estranes Estrogen ethers Synthetic estrogens Conjugated estrogens Estrogen (medication) Oral administration Multiple myeloma Myocardial infarction Lipid profile Steroid Clinical trial Feminization (biology) Estriol (medication) dbr:Ethinylestradiol Breast pain Osteoporosis Hypolipidemic agents Gynecomastia Atherosclerosis Blood lipids Bone metastasis Bone pain Side effect SC-4289 Triparanol Estrogen ether Synthetic compound Preclinical research
sameAs	Mytatrienediol Mytatrienediol Mytatrienediol
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Genito-urinary-drug-stub dbt:Reflist dbt:Short_description dbt:Steroid-stub
thumbnail	wiki-commons:Special:FilePath/Mytatrienediol.svg?width=300
c	20 (xsd:integer)
CAS number	5108 (xsd:integer)
ChEBI	34859 (xsd:integer)
ChemSpiderID	4445527 (xsd:integer)
class	Estrogen (medication) Estrogen ether
H	28 (xsd:integer)
IUPAC name	-3 (xsd:integer)
KEGG	14242.0 (nicaraguanCórdoba)
O	3 (xsd:integer)
PubChem	5282364 (xsd:integer)
routes of administration	Oral administration
SMILES	CC12CCC3CCCC4=C3C=CCOC (en)
StdInChI	1 (xsd:integer)
StdInChIKey	OOVXZFCPCSVSEM-NADOGSGZSA-N (en)
synonyms	SC-6924; Manvene; Anvene; (3-Methoxy-16α-methylestra-1,3,5-triene-16β,17β-diol; 16α-Methylestriol 3-methyl ether; 16β-Hydroxy-16α-methylestradiol 3-methyl ether) (en)
UNII	1 (xsd:integer)
width	225 (xsd:integer)
has abstract	Mytatrienediol (developmental code name SC-6924; former tentative brand names Manvene, Anvene), also known as 16α-methyl-16β-epiestriol 3-methyl ether or 16β-hydroxy-16α-methylestradiol 3-methyl ether, is a synthetic steroidal estrogen medication and an estrogen ether which was derived from estriol and was developed for clinical use in the late 1950s but was never marketed. It was investigated as a weak and mildly estrogenic medication for men to treat atherosclerosis, improve serum lipid profiles, and reduce the risk of myocardial infarction. However, while preclinical research supported the profile of mytatriendiol as a weak estrogen, the medication was found in clinical trials to produce estrogenic side effects including feminization, breast pain, and gynecomastia in men similarly and comparably to other estrogens such as ethinylestradiol and conjugated estrogens, and its side effects ultimately precluded its use. The medication was also studied to treat bone pain in patients with multiple myeloma, metastatic bone disease, and osteoporosis, with effectiveness seen. (en)
prov:wasDerivedFrom	wikipedia-en:Mytatrienediol?oldid=1084549142&ns=0
page length (characters) of wiki page	7285 (xsd:nonNegativeInteger)
CAS number	5108-94-1
ChEBI	34859
FDA UNII code	1G3TKH1O14
KEGG	C14242
PubChem	5282364
class	Estrogen (medication) Estrogen ether
foaf:isPrimaryTopicOf	wikipedia-en:Mytatrienediol
is Link from a Wikipage to another Wikipage of	Epiestriol List of estrogen esters List of estrogens C20H28O3 16α-Iodo-E2 Clomestrone Estriol (medication) Anvene SC-4289 Triparanol SC-6924 SC6924 SC 6924 Manvene

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