About: N-Arachidonylglycine

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N-Arachidonylglycine (NAGly) is a carboxylic metabolite of the endocannabinoid anandamide (AEA). Since it was first synthesized in 1996, NAGly has been a primary focus of the relatively contemporary field of lipidomics due to its wide range of signaling targets in the brain, the immune system and throughout various other bodily systems. In combination with 2‐arachidonoyl glycerol (2‐AG), NAGly has enabled the identification of a family of lipids often referred to as endocannabinoids. Recently, NAGly has been found to bind to G-protein coupled receptor 18 (GPR18), the putative abnormal cannabidiol receptor. NaGly is an endogenous inhibitor of fatty acid amide hydrolase (FAAH) and thereby increases the ethanolamide endocannabinoids AEA, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Chemical compound chemical compound drug
rdfs:label	N-Arachidonylglycine (en)
rdfs:comment	N-Arachidonylglycine (NAGly) is a carboxylic metabolite of the endocannabinoid anandamide (AEA). Since it was first synthesized in 1996, NAGly has been a primary focus of the relatively contemporary field of lipidomics due to its wide range of signaling targets in the brain, the immune system and throughout various other bodily systems. In combination with 2‐arachidonoyl glycerol (2‐AG), NAGly has enabled the identification of a family of lipids often referred to as endocannabinoids. Recently, NAGly has been found to bind to G-protein coupled receptor 18 (GPR18), the putative abnormal cannabidiol receptor. NaGly is an endogenous inhibitor of fatty acid amide hydrolase (FAAH) and thereby increases the ethanolamide endocannabinoids AEA, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA (en)
foaf:name	N-Arachidonylglycine (en)
name	N-Arachidonylglycine (en)
foaf:depiction
dct:subject	Arachidonyl compounds Endocannabinoids Fatty acid amides Substances discovered in the 1990s Glycine reuptake inhibitors
Wikipage page ID	35912300 (xsd:integer)
Wikipage revision ID	1072468740 (xsd:integer)
Link from a Wikipage to another Wikipage	Prostaglandins Sciatic nerve Metabolite GPR18 TNFα Endocannabinoid system Endometriosis Glycine dbr:Arachidonic_acid Lipids Fatty acid amide hydrolase Microglia 2-Arachidonoylglycerol GPR55 Lipidomics Abnormal cannabidiol Agonist Anandamide dbr:Farnesyl_pyrophosphate Palmitoylethanolamide Carboxylic acid Endocannabinoids Endometrial HEK cell Arachidonyl compounds Endocannabinoids Fatty acid amides Substances discovered in the 1990s Tetrahydrocannabinol Hyperalgesia Glycine reuptake inhibitors FAAH Insulin Oleoylethanolamide Ethanolamide Secretagogue PM20D1 Freund adjuvant IFNγ Dorsal root ganglia Cyclooxygenase-2
sameAs	N-Arachidonylglycine N-Arachidonylglycine N-Arachidonylglycine N-Arachidonylglycine N-Arachidonylglycine
dbp:wikiPageUsesTemplate	dbt:Cannabinoidergics dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Glycinergics
thumbnail	wiki-commons:Special:FilePath/N-Arachidonoyl_Glycine.svg?width=300
ImageFile	N-Arachidonoyl Glycine.svg (en)
OtherNames	N-Arachidonylglycine (en) Arachidonoyl glycine (en) NA-glycine (en)
PIN	[-Icosa-5,8,11,14-tetraenamido]acetic acid (en)
Verifiedfields	changed (en)
verifiedrevid	464364547 (xsd:integer)
has abstract	N-Arachidonylglycine (NAGly) is a carboxylic metabolite of the endocannabinoid anandamide (AEA). Since it was first synthesized in 1996, NAGly has been a primary focus of the relatively contemporary field of lipidomics due to its wide range of signaling targets in the brain, the immune system and throughout various other bodily systems. In combination with 2‐arachidonoyl glycerol (2‐AG), NAGly has enabled the identification of a family of lipids often referred to as endocannabinoids. Recently, NAGly has been found to bind to G-protein coupled receptor 18 (GPR18), the putative abnormal cannabidiol receptor. NaGly is an endogenous inhibitor of fatty acid amide hydrolase (FAAH) and thereby increases the ethanolamide endocannabinoids AEA, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) levels. NaGly is found throughout the body and research on its explicit functions is ongoing. (en)
gold:hypernym	Analog
prov:wasDerivedFrom	wikipedia-en:N-Arachidonylglycine?oldid=1072468740&ns=0
page length (characters) of wiki page	17084 (xsd:nonNegativeInteger)
alternative name	N-Arachidonylglycine (en) Arachidonoyl glycine (en) NA-glycine (en)
IUPAC name	[(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamido]acetic acid (en)
foaf:isPrimaryTopicOf	wikipedia-en:N-Arachidonylglycine
is Link from a Wikipage to another Wikipage of	Psychoactive drug C22H35NO3 Sodium- and chloride-dependent glycine transporter 2 N-Acylethanolamine NAGly receptor Arachidonylglycine N-arachidonoyl glycine

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