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About: Naloxazone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:ChemicalSubstanceType, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:Abstraction100002137yago:Agent114778436yago:Alcohol107884567yago:AliphaticCompound114601294yago:Alkene114713120yago:Beverage107881800yago:CausalAgent100007347yago:Chemical114806838yago:Compound114818238yago:Drug103247620yago:DrugOfAbuse103248958yago:Element114840755yago:Fluid114939900yago:Food100021265yago:Liquid114940386yago:Material114580897yago:Matter100020827yago:OrganicCompound114727670yago:Part113809207yago:Phenol114989545yago:PhysicalEntity100001930yago:Quintessence114847103yago:Relation100031921chemical compounddrugyago:Substance100019613yago:Substance100020090yago:WikicatAlcoholsyago:WikicatAlkenesyago:WikicatEthersyago:WikicatPhenolsumbel-rc:ChemicalSubstanceType New Facet based on Instances of this Class

Naloxazone is an irreversible μ-opioid receptor antagonist which is selective for the μ1 receptor subtype. Naloxazone produces very long lasting antagonist effects as it forms a covalent bond to the active site of the μ-opioid receptor, thus making it impossible for the molecule to unbind and blocking the receptor permanently until the receptor is recycled by endocytosis.