Nathaniel W. Watkins (January 28, 1796 – March 20, 1876) was a Kentucky-born soldier, lawyer, and Missouri politician who was also a half-brother to prominent nineteenth-century Kentucky politician Henry Clay. He served as a Confederate militia brigadier general during the American Civil War and before that in the War of 1812 and the Mexican–American War. He was a member of the Missouri State Senate and a Speaker of the Missouri House of Representatives. Watkins was also a founder of the city of Morley, Missouri.